Computational modeling of endovascular peripheral nerve stimulation using a stent-mounted electrode array

Abstract

Objective. Endovascular neuromodulation has attracted substantial interest in recent years as a minimally invasive approach to treat neurological disorders. In this study, we investigated with a computational model the feasibility of stimulating peripheral nerves with an endovascular stent-mounted electrode array. Approach. Anatomically realistic FEM models were constructed for the pudendal and vagal neurovascular bundles. The electromagnetic fields generated from electrical stimuli were computed using Sim4Life NEURON models to predict dynamic axonal responses. Main results. The models predict that the stimulation thresholds of the endovascular stent-electrode array configurations tested are..